| Autor: |
Miller FJ, Graham JA, Illing JW, Gardner DE |
| Jazyk: |
angličtina |
| Zdroj: |
Toxicology letters [Toxicol Lett] 1980 Sep; Vol. 6 (4-5), pp. 267-74. |
| DOI: |
10.1016/0378-4274(80)90131-9 |
| Abstrakt: |
The influence of nitrogen dioxide (NO2) on pentobarbital (PEN)-induced sleeping time (S.T.) was investigated in mice. Acute exposure to concentractions as low as 470 microgram NO2/m3 (0.25 ppm) caused a significant increase in PEN-induced S.T. No significant effects on PEN-induced S.T. were detected after 1 or 2 days (3 h/day) exposure to 235 microgram NO2/m3 (0.125 ppm). None of the exposure regimens affected the time required for the drug to induce sleep. When the effects of repeated daily exposures (3 h/day) to 9400 microgram NO2/m3 (5 ppm) were compared in male and female mice, the females had a significantly increased PEN-induced S.T. after 1 and 2 days of exposure. However, an increase in PEN-induced S.T. was not observed in males until the 3rd day of exposure. Since the duration of PEN-induced S.T. is primarily determined by hepatic mixed function oxidase activity, it is possible that NO2 may alter some aspects of xenobiotic metabolism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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