Manipulation of duration of action of a synthetic prostaglandin analogue (TPT) assessed in the pregnant beagle bitch.

Autor: Vickery BH, McRae GI, Kent JS, Tomlinson RV
Jazyk: angličtina
Zdroj: Prostaglandins and medicine [Prostaglandins Med] 1980 Aug; Vol. 5 (2), pp. 93-100.
DOI: 10.1016/0161-4630(80)90096-8
Abstrakt: Beagle bitches were treated on days 20-22 of pregnancy with TPT as an aqueous solution administered subcutaneously via a minipump at a rate of 10 micrograms per hour for either 24 (I) or 48 hours (II). Additional animals received a single subcutaneous injection of 200 micrograms of TPT as an aqueous solution (III) or dissolved in polyethylene glycol 400 (IV) or the methyl ester of TPT dissolved in polyethylene glycol 400 (V). The duration of action was assessed by the nadir in circulating progesterone levels. By this criterion the duration of action in the different groups ranked I=III
Databáze: MEDLINE