Clearance of immune complexes formed in normal and leukaemic rats.

Autor: Shepherd PS, Pendry RA, Dean CJ
Jazyk: angličtina
Zdroj: British journal of cancer [Br J Cancer] 1980 Apr; Vol. 41 (4), pp. 562-6.
DOI: 10.1038/bjc.1980.98
Abstrakt: Immune complexes of 125I-HSA-rat anti-HSA formed in vivo under conditions of antibody excess were rapidly cleared from the circulation of both normal and leukaemic Hooded rats. In HSA-immune rats most of the 125I-HSA present in the blood was found to be cell-bound, but a proportion was present as circulating immune complexes that could be precipitated from plasma by 2.5% polyethylene glycol. There was no evidence that clearance of a soluble antigen was impaired in leukaemic animals.
Databáze: MEDLINE