| Autor: |
Emmertsen K, Nielsen HE, Mosekilde L, Hansen HH |
| Jazyk: |
angličtina |
| Zdroj: |
Acta medica Scandinavica [Acta Med Scand] 1980; Vol. 207 (5), pp. 367-9. |
| DOI: |
10.1111/j.0954-6820.1980.tb09739.x |
| Abstrakt: |
The effect of cimetidine on basal and pentagastrin-stimulated serum immunoreactive calcitonin (S-iCT) concentrations was studied in six patients with medullary carcinoma of the thyroid (MCT). Basal S-iCT was elevated in all patients and showed a marked increase after i.v. injection of pentagastrin, 0.5 micrograms/kg b.wt. Cimetidine, 200 mg i.v., 30 min before administration of pentagastrin had no effect on either basal or pentagastrin-stimulated S-iCT. Thus, the mechanisms of basal and pentagastrin-stimulated calcitonin secretion from MCT do not seem to involve agonism with histamine H2-receptors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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