High-performance liquid chromatographic separation of carbamazepine metabolites excreted in rat urine.

Autor: Horning MG, Lertratanangkoon K
Jazyk: angličtina
Zdroj: Journal of chromatography [J Chromatogr] 1980 Jan 11; Vol. 181 (1), pp. 59-65.
DOI: 10.1016/s0378-4347(00)81269-4
Abstrakt: A procedure for the separation and isolation of the urinary metabolites of carbamazepine by reversed-phase high-performance liquid chromatography is described. After extraction from urine, the metabolites were separated on either an analytical or semi-preparative C18 mu Bondapak column by gradient elution with methanol-water-acetic acid. Following derivatization the metabolites isolated by the use of the semi-preparative column were analyzed by gas chromatography and gas chromatography-mass spectrometry.
Databáze: MEDLINE