[Immune response of mice to experimental influenza].

Autor: Ageeva ON, Sorokina IuD, Alibaeva RA, Barmicheva NM, Krauklis NG
Jazyk: ruština
Zdroj: Voprosy virusologii [Vopr Virusol] 1981 Nov-Dec (6), pp. 701-6.
Abstrakt: The immune response of BALB/c mice to a pathogenic and nonpathogenic strains of influenza type A virus was studied. In this system of experimental influenza infection the pathogenic influenza A/PR8/34 (HON1) virus was found to induce sensitization of T-lymphocytes and production of clones cytotoxic for syngeneic target cells. Nonpathogenic influenza A/Krasnodar/101/59 (H2N2) virus had a less marked capacity to induce sensitization of lymphocytes and production of clones cytotoxic for syngeneic target cells. But the nonpathogenic virus strain had a sufficiently high mitogenic activity and stimulated proliferation of lymphocytes sensitized by a heterogenous influenza virus strain.
Databáze: MEDLINE