| Autor: |
Ritschel WA, Bykadi G, Norman EJ, Cluxton RJ, Denton D |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of clinical pharmacology [J Clin Pharmacol] 1981 Nov-Dec; Vol. 21 (11), pp. 461-5. |
| DOI: |
10.1002/j.1552-4604.1981.tb05650.x |
| Abstrakt: |
A total of 25 plasma and saliva samples were obtained from three hospital inpatients upon intravenous short-time infusion of cyclophosphamide; total doses infused ranged from 5.3 to 13.3 mg/kg. Despite interindividual variations, a correlation was found for plasma-to-saliva ratio of 1.61 +/- 0.53 (S.D.). Our Saliva-to-plasma ratio of 0.62 is in agreement with a recently reported ratio of 0.77. The ratio stayed constant throughout the observation period (0.5 to 8.4 hours), indicating that the noninvasive method of saliva sampling seems to be a useful approach in cyclophosphamide drug concentration monitoring in patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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