| Autor: |
Nannini G, Perrone E, Severino D, Casabuona F, Bedeschi A, Buzzetti F, Giraldi PN, Meinardi G, Monti G, Ceriani A, de Carneri I |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1981 Nov; Vol. 34 (11), pp. 1456-68. |
| DOI: |
10.7164/antibiotics.34.1456 |
| Abstrakt: |
The synthesis and in vitro activity of 7-vinylenethioacetamido cephalosporins with a tetrazolo-pyridazine at the 3-position are described. These cephalosporins showed good activity against Gram-positive and Gram-negative bacteria. 7-[(Z)-beta-carboxyvinylenethio-acetamido]-3-[(tetrazolo[1,5-b]pyridazin-8- amino-6-yl)-thiomethyl]-3-cephem-4-carboxylic acid (K 13176, 21) was significantly more active in vitro and in vivo than cefazolin against Gram-negative bacteria. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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