| Autor: |
Rowe AE, Cowan BM, Eddleston AL, Thomson AD |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and experimental immunology [Clin Exp Immunol] 1981 Aug; Vol. 45 (2), pp. 305-7. |
| Abstrakt: |
An attempt was made to produce a model of autoimmune hepatitis in AKR mice by immunization with allogeneic liver extract or a purified (human) liver-specific lipoprotein (LSP). Although a mononuclear infiltrate was found in the liver in recipients of purified liver antigen and to a lesser degree in recipients of allogeneic extract, this was associated with the development of an acute thymus-derived leukaemia. This mouse strain is normally susceptible to leukaemia after a latent period of approximately 6 to 9 months but the immunization schedule markedly reduced the age of onset of this disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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