| Autor: |
Gagel'gans AI, Asrarov MI, Kazakov I, Shkinev AV, Mirkhodzhaev UZ |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 1981 Nov-Dec; Vol. 26 (6), pp. 1004-10. |
| Abstrakt: |
It has been found earlier in Lehninger's Laboratory [24] that oxidation of endogenous PN mitochondria induced by oxalacetic acid (OAA) brings about the release of accumulated Ca2+. Analysis of possible mechanism of this phenomenon has shown that OAA has protonophore activity on mitochondria and BPM unlike the malate--the product of enzymic reduction of OAA in the presence of NAD . H. OAA-induced permeability of BPM and mitochondria membranes for H+ is observed at pH 7.5-8.0 and is insignificant at pH 7.0 and lower. Possible function of OAA as a soft uncoupler-protonophore controlled by metabolism is discussed, in particular--in connection with Ca2+ transport in mitochondria. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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