| Autor: |
Soullier BK, Wilson PS, Nigro ND |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1981 May; Vol. 12 (4), pp. 343-8. |
| DOI: |
10.1016/0304-3835(81)90177-4 |
| Abstrakt: |
The effects of selenium supplementation on azoxymethane-induced intestinal cancer were studied in male Sprague- Dawley rats given 8 weekly injections of azoxymethane (8 mg/kg body wt), and fed a 30% beef fat diet. Selenium-supplemented groups received 8 ppm H2SeO3 in drinking water. Blood selenium levels of supplemented rats increased rapidly the first 9 weeks of the experiment, followed by a plateau significantly higher than that for non-selenium controls. There was a significantly increase in liver and intestinal selenium levels in supplemented groups. The average number of intestinal tumors was 6.5 in the control group, and 3.1 in the selenium-supplemented group. There was a significant reduction in tumor incidence in the proximal half of the colon of selenium-treated rats. There was also increased concentration of tissue selenium in the proximal half of the colon of these rats. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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