| Autor: |
Laszlo J, Lucas VS Jr, Hanson DC, Cronin CM, Sallan SE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of clinical pharmacology [J Clin Pharmacol] 1981 Aug-Sep; Vol. 21 (S1), pp. 51S-56S. |
| DOI: |
10.1002/j.1552-4604.1981.tb02573.x |
| Abstrakt: |
Thirty five patients were enrolled into a Phase I-II study of oral levonantradol being tested as an antiemetic for chemotherapy patients who were refractory to the aggressive use of standard antiemetic agents. Sixty-nine total courses were given. Dysphoric reactions (fear, anxiety, hallucinations) were the most serious side effects, and were most prevalent at the highest dose tested (2.0 mg q4h). Somnolence, a "high" feeling, hypotension were also noted. Antiemetic responses were seen at 0.5, 1.0, 1.5 and 2.0 mg dose levels: the two intermediate doses gave responses comparable to those previously reported for oral THC. It is suggested that a combination of oral and parenteral levonantradol may prove to be a very effective program to relieve the otherwise disabling problems of persistent nausea and vomiting. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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