Biochemical effects of some organophosphorus insecticide on new targets in white rats.

Autor: El-Sebae AH, Enan EE, Soliman SA, El-Fiki S, Khamees E
Jazyk: angličtina
Zdroj: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes [J Environ Sci Health B] 1981; Vol. 16 (4), pp. 475-91.
DOI: 10.1080/03601238109372273
Abstrakt: The three S-n-propyl phosphates and phosphothioates: RH 218, profenofos and prothiophos were compared with fenitrothion in their potential as inhibitors of rat liver and brain AChE. Fenitrothion was more potent as an inhibitor than the three S-n-propyl derivatives. Incubation of hepatic protein enhanced ChE inhibition in brain in the case of fenitrothion, while it reduced the inhibitory effect of the S-n-propyl derivatives. On the other hand, the four organophosphorus esters caused hypoglycemia in both male and female rats and also reduced their blood urea with different degrees.
Databáze: MEDLINE