| Autor: |
Haskell TH, Woo PW, Nicolaides ED, Hutt MP, Huang GG, Sanchez JP, DeJohn D, Heifetz CL, Krolls U, Lunney E, Mich TF |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1981 Jul; Vol. 34 (7), pp. 862-8. |
| DOI: |
10.7164/antibiotics.34.862 |
| Abstrakt: |
The synthesis and biological activities of a series of 12 new semisynthetic penicillins is described. These compounds consisted of acylated amino acid analogs of 6-substituted-1,2-dihydro-2-oxonicotinic acid and 2-substituted-3,4-dihydro-4-oxo-5-pyrimidinecarboxylic acid attached to amoxicillin. The effect of the amino acid substituent, chirality of amino acid and acyl function on biological properties is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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