| Autor: |
Lankelma J, Penders PG, Leyva A, Pinedo HM |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1981 Mar; Vol. 12 (1-2), pp. 131-7. |
| DOI: |
10.1016/0304-3835(81)90048-3 |
| Abstrakt: |
The determination of thioproline in plasma of cancer patients, using high performance liquid chromatography (HPLC) is reported. As column support, a silica-bonded cation exchanger was used. Detection was performed at 205 nm. The detection limit of the method was 5 X 10(-6) M and the linear dynamic range was over 500. No sample clean-up procedure was necessary other than deproteinization of the plasma. The method was applied to the measurement of plasma drug levels in 3 patients, part of a clinical trial testing the effectiveness of thioproline as an anti-cancer agent. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
