| Autor: |
Koppel GA, Haisch KD, Spaethe SM, Schmidtke JR, Fleisch JH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pharmacological methods [J Pharmacol Methods] 1981 Aug; Vol. 6 (1), pp. 39-43. |
| DOI: |
10.1016/0160-5402(81)90082-6 |
| Abstrakt: |
A method was developed to induce contraction of immunologically sensitized mouse trachea by antigen (Schultz-Dale reaction). The response was mediated by immunoglobulin (Ig) E antibody directed against either the hapten DNP, the hapten carrier conjugate DNP-keyhole limpet hemocyanin (KLH), or the unmodified carrier KLH. Tracheal contractions were elicited by DNP-KLH, KLH, or DNP-bovine serum albumin (BSA) but not by DNP or BSA alone. This procedure represents a useful index of in vitro anaphylaxis in mouse airway smooth muscle. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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