[Selective induction of tumors in Wistar rats with loop colostomy after administration of methyl-(acetoxymethyl)-nitrosamine (MAOMN) (author's transl)].

Autor: Doertenbach J, Ivankovic S, Junghanns K, Siebert A, Hettler J, Wiessler M, von Gerstenbergk L
Jazyk: němčina
Zdroj: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 1981; Vol. 100 (1), pp. 19-23.
DOI: 10.1007/BF00405898
Abstrakt: A single dose of 7 mg/kg methyl-(acetoxymethyl)-nitrosamine in Wistar rats with double loop colostomy induced adenomas, papillomas, and adenocarcinomas at the site of colostomy in 83% of the treated animals. The mean induction time was 320 days. The pronounced local effect as well as the high tumor yield are discussed in regard to the evident high epithelial sensitivity at the colostomy site.
Databáze: MEDLINE