| Autor: |
Kudriavtseva GV, Denisova II |
| Jazyk: |
ruština |
| Zdroj: |
Biokhimiia (Moscow, Russia) [Biokhimiia] 1980 Jan; Vol. 45 (1), pp. 118-23. |
| Abstrakt: |
Using hormonal induction by thyroxin, the half-life time and the rate constants for the synthesis and degradation of glucose-6-phosphate dehydrogenase and transketolase were determined. It was shown that the mechanisms of activation of these enzymes by thyroxin are different. Under hyperthyrosis an increase in the activity of glucose-6-phosphate dehydrogenase is induced by a decrease (2-fold) of the degradation rate constant; the rate constant of synthesis is not changed thereby, while the half-life time for the enzyme increases 2-fold. The activation of transketolase in this case can be accounted for by an almost 1,5-fold increase in the rate of the enzyme synthesis, whereas the degradation rate constant and the half-life time of the enzyme remain practically unchanged. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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