| Autor: |
Mandersloot JG, Gerritsen WJ, Leunissen-Bijvelt J, van Echteld CJ, Noordam PC, de Gier J |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1981 Jan 08; Vol. 640 (1), pp. 106-13. |
| DOI: |
10.1016/0005-2736(81)90536-8 |
| Abstrakt: |
(1) A selective increase in permeability is induced in cardiolipin/phosphatidylcholine bilayers at Ca2+ concentrations of 1--3 mM. At higher concentrations of Ca2+ the permeability barrier is completely destroyed. (2) The selective increase in permeability is correlated with the formation of lipid particles visualized by freeze-fracture electron microscopy and an isotropic signal in 31P-NMR spectra. (3) Lowering the Ca2+ concentration shows reduction in permeability but the formation of the lipid particles is a non-reversible process. (4) At higher Ca2+ concentrations, 31P-NMR spectra and freeze-fracture results indicate the formation of the hexagonal phase, explaining the disappearance of the permeability barrier. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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