| Autor: |
Bogema SC, Narasimhachari N, Mumtaz M, Goldin S, Friedel RO |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of chromatography [J Chromatogr] 1982 Dec 10; Vol. 233, pp. 257-67. |
| DOI: |
10.1016/s0378-4347(00)81752-1 |
| Abstrakt: |
A high-performance liquid chromatographic procedure is described for the separation of cis and trans isomers of thiothixene, a thioxanthene derivative used as an antipsychotic agent. A radial compression module (RCM-100) was used with both silica and cyanopropyl cartridges. A fixed-wavelength UV detector (254 nm) was used in these studies for quantitation. Mesoridazine is used as an internal standard because of its separation characteristics and reproducible quantitation. C18 Sep-Pak cartridges are used for biological sample clean-up. Plasma samples from patients treated with thiothixene (Navane) were assayed for cis and trans-thiothixene. No trans-thiothixene was detectable and cis-thiothixene concentrations ranged from 0 to 22.5 ng/ml. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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