| Autor: |
Evans DB, Schenden JA, Bristol JA |
| Jazyk: |
angličtina |
| Zdroj: |
Life sciences [Life Sci] 1982 Nov 29; Vol. 31 (22), pp. 2425-32. |
| DOI: |
10.1016/0024-3205(82)90746-9 |
| Abstrakt: |
Several adenosine analogs were evaluated for their effects on rate and contractility in guinea pig isolated atria. Among adenosine agonists, (-)-N-(1-methyl-2-phenylethyl) adenosine (l-phenylisopropyladenosine; l-PIA) and N-cyclohexyladenosine (CHA), decreased rate and force at nanomolar concentrations, whereas 2-chloroadenosine, N,N-dimethyladenosine (N6-dimethyladenosine) and (+)-N-(1-methyl-2-phenylethyl)adenosine (d-phenylisopropyladenosine; d-PIA) were less potent cardiac depressants. The degree and order of potency of these agonists suggest that the cardiac depressant effects of adenosine are mediated via A1-receptors. The cardiac depressant effects of CHA and l-PIA were antagonized by theophylline and 1,3-diethyl-8-phenylxanthine (DPX). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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