| Autor: |
Rush GF, Adler VL, Hook JB |
| Jazyk: |
angličtina |
| Zdroj: |
Toxicology letters [Toxicol Lett] 1982 Aug; Vol. 12 (4), pp. 265-71. |
| DOI: |
10.1016/0378-4274(82)90250-8 |
| Abstrakt: |
Administration of ethanol in the drinking water increases hepatic cytochrome P-450 content and xenobiotic metabolism. However, the effect on renal xenobiotic metabolism has not been investigated. Chronic consumption of ethanol (15% solution in the drinking water) increased hepatic cytochrome P-450 content as well as ethoxycoumarin-O-deethylase, aniline hydroxylase and benzphetamine-N-demethylase activities. No change in renal cytochrome P-450 was detected after chronic ethanol consumption whereas ethoxycoumarin-O-deethylase activity in renal microsomes was significantly increased. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
