Induction of metallothionein in the rat brain by copper implantation but not by cobalt implantation.

Autor: Waalkes MP, Ross SM, Craig CR, Thomas JA
Jazyk: angličtina
Zdroj: Toxicology letters [Toxicol Lett] 1982 Jul; Vol. 12 (2-3), pp. 137-42.
DOI: 10.1016/0378-4274(82)90176-x
Abstrakt: Following gel-filtration of cytosol prepared from copper-implanted rat brain there was a pronounced copper-containing, cadmium-binding peak with a relative elution volume similar to that of hepatic metallothionein (MT). No such peak was apparent in cytosol derived from cobalt- or glass-implanted brains. Spectral analysis of a purified protein from copper-implanted brain reveal a UV absorption spectrum characteristic of MT.
Databáze: MEDLINE