The biological activity of retinotaurine.
| Autor: | Skare KL, Sietsema WK, DeLuca HF |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of nutrition [J Nutr] 1982 Aug; Vol. 112 (8), pp. 1626-30. |
| DOI: | 10.1093/jn/112.8.1626 |
| Abstrakt: | The ability of the biliary metabolite retinotaurine to reverse the cornification of vaginal epithelial cells induced by vitamin A deficiency was assessed using a vaginal smear assay. Retinotaurine activity was examined following the intravaginal administration of 10(-12) mol to 10(-8) mol of this compound per vagina. This metabolite exhibited no detectable activity at any dose tested. These results show that retinotaurine cannot be more than 1% as active as all-trans-retinoic acid since retinoic acid shows a response at concentrations of 10(-10) mol per vagina. The low biological activity of this recently identified biliary metabolite suggests that it represents an excretory form of retinoic acid. |
| Databáze: | MEDLINE |
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