| Autor: |
Das BP, Zalkow VB, Forrester ML, Molock FF, Boykin DW |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pharmaceutical sciences [J Pharm Sci] 1982 Apr; Vol. 71 (4), pp. 465-6. |
| DOI: |
10.1002/jps.2600710426 |
| Abstrakt: |
A series of 1,4-bis(4-guanylphenylethyl)benzenes, including masked amidines in which the guanyl function is incorporated into a heterocyclic ring, were prepared for screening as potential antitrypanosomal agents. Some of these compounds were active against Trypanosoma rhodesiense in mice. The diamidines were prepared by standard methods from 1,4-bis(4-cyanophenylethyl)benzene which was obtained from 1,4-bis(4-cyanostyryl)benzene by diimide reduction. The latter compound was prepared by the Wittig reaction between 4-cyanobenzylphosphonium ylide and terephthaldicarboxaldehyde. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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