| Autor: |
Hruska RE, Pitman KT, Silbergeld EK, Ludmer LM |
| Jazyk: |
angličtina |
| Zdroj: |
Life sciences [Life Sci] 1982 Feb 07; Vol. 30 (6), pp. 547-53. |
| DOI: |
10.1016/0024-3205(82)90268-5 |
| Abstrakt: |
Administration of prolactin to adult male rats, by S.C. injection, significantly increases the density of the striatal dopamine (DA) receptors, without altering the apparent affinity of the receptors for [3H]spiroperidol. Larger doses of prolactin are required to increase the density of the striatal DA receptors in hypophysectomized rats compared to normal rats. These results suggest that prolactin might be the common mediator of the increase in striatal DA receptor density produced by either estrogen or haloperidol administration. Monitoring and/or altering prolactin levels might be informative in neurologic or psychiatric disorders involving striatal DA neurotransmission. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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