| Autor: |
Echenique RL, Kasi L, Haynie TP, Glenn HJ, Samaan NA, Hill CS |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 1982 Mar; Vol. 23 (3), pp. 235-40. |
| Abstrakt: |
Serum thyroglobulin measurements by radioimmunoassay were performed in the follow-up of 68 patients with differentiated thyroid carcinoma undergoing I-131 total-body scans following surgery and/or I-131 therapy. Of 12 patients with distant metastases demonstrated by I-131 scan, thyroglobulin levels were elevated (greater than 60 ng/ml) in nine (75%); the remaining 25% either ranged between 20 and 60 ng/ml or were below 20 ng/ml in spite of having functional metastases. Of six patients with only regional lymph-node metastases demonstrated by I-131 scan, only one (16%) had an elevated thyroglobulin level, while two fell in the 20-60 ng/ml range and three were below 20 ng/ml. Of the remaining patients with no metastatic disease demonstrable by I-131 scan, three (6%) had elevated thyroglobulin levels. These patients were subsequently found to have metastatic disease by other criteria. These results suggest caution in the use of thyroglobulin levels as a replacement for I-131 scans in the follow-up of differentiated thyroid carcinoma. Based on our study, however, the two methods complement each other to achieve maximum sensitivity and reliability. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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