Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?

Autor: van Veelen CW, Staal GE, Verbiest H, Vlug AM
Jazyk: angličtina
Zdroj: Lancet (London, England) [Lancet] 1977 Aug 20; Vol. 2 (8034), pp. 384-5.
DOI: 10.1016/s0140-6736(77)90308-7
Abstrakt: In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine. This study demonstrates the appearance of the MII-type isoenzyme in various gliomas. This MII type is also found in meningiomas but not in normal brain tissue. The method of enzyme examination described may be valuable as a diagnostic aid in the surgery of gliomas.
Databáze: MEDLINE