| Autor: |
Hartmann DW, Entringer MA, Robinson WA, Vasil ML, Drebing CJ, Morton NJ, True L |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of cellular physiology [J Cell Physiol] 1981 Oct; Vol. 109 (1), pp. 17-24. |
| DOI: |
10.1002/jcp.1041090103 |
| Abstrakt: |
Studies have been carried out to determine the effect of bacterial infection on CSF production, CFU-C activation, and bacterial clearance by mature granulocytes in mice infected with Escherichia coli. These studies have shown that immediately after bacterial infection (5 minutes), serum colony-stimulating factor (CSF) levels and bone marrow colony-forming units in culture (CFU-C) levels are elevated. This is followed by oscillatory rises in both of these parameters and the appearance of granulocytes in the infected site. With clearance of bacteria, CSF and CFU-C levels return to normal. These studies have indicated further that bacterial infection is a major stimulus for granulocyte production through the CSF-CFU-C system and that clearance of bacteria by mature granulocytes may serve as a negative feedback regulatory arm. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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