Influenza B at Christ's Hospital: natural antibody to influenza B estimated by radial haemolysis.
| Autor: | Grilli EA, Davies JR |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Journal of hygiene [J Hyg (Lond)] 1981 Oct; Vol. 87 (2), pp. 211-8. |
| DOI: | 10.1017/s0022172400069424 |
| Abstrakt: | The technique of radial haemolysis (SRH) was used to assess the response to infection with different strains of influenza B virus, to determine the persistence of antibody following such infection and to examine sera from boys entering school at age 11 years. The technique detected 95% of infections and in primary infection the antibody response was mainly to the infecting strain. Re-infections resulted in a broad response, both to the homotypic strain and to strains more distantly related. Antibody to the homotypic strain persisted for at least 3 years but in some individuals the reaction with heterotypic strains tended to become weaker--resulting in zones of incomplete lysis--or was lost. Examination of the sera collected on entry to the school showed that about 60% of the boys bled before B/Hong Kong became widespread in the United Kingdom had antibody to strains representative of those isolated in the 1960s and few boys had antibody to B/Hong Kong. After 1974 antibody to B/Hong Kong and later strains became more common while antibody to earlier strains was less frequently detected. The significance of the results as an estimate of past experience is discussed. |
| Databáze: | MEDLINE |
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