Maturation of early-phase insulin release in the neonatal lamb.

Autor: Philipps AF, Dubin JW, Raye JR
Jazyk: angličtina
Zdroj: Biology of the neonate [Biol Neonate] 1981; Vol. 39 (5-6), pp. 225-31.
DOI: 10.1159/000241441
Abstrakt: Standardized primed continuous glucose infusions were performed in 13 newborn lambs between 4 h and 2 weeks of age to assess the timing of development of glucose-induced early-phase insulin release. Lambs of less than 6 h of age behaved similar to those previously infused in utero, with no early response noted. In contrast, early-phase insulin release was present in lambs of 12 h of age and older. Although basal plasma glucose rose with increasing post-natal age, this rise was not sufficient to account for the appearance of early-phase insulin release. Factors other than the basal glucose level or the birth process itself may be operative.
Databáze: MEDLINE