| Autor: |
Adam HK, Kay B, Douglas EJ |
| Jazyk: |
angličtina |
| Zdroj: |
Anaesthesia [Anaesthesia] 1982 May; Vol. 37 (5), pp. 536-40. |
| DOI: |
10.1111/j.1365-2044.1982.tb01223.x |
| Abstrakt: |
The blood concentrations of disoprofol (Diprivan) after single intravenous doses of 1, 2 or 3 mg/kg have been examined in a subpopulation from previously reported clinical studies. The linear relationship between sleep time and dose could be explained by the linearity of the pharmacokinetics at these doses. After a single injection the awakening concentration was independent of dose, with a mean value of 1.04 micrograms/ml. No acute tolerance occurred with disoprofol. On repeated 1 mg/kg bolus injections the sleeping time rose initially but stabilised after four doses. The waking concentration was independent of the number of doses administered. The clinical findings fitted an agent with a very rapid distribution phase and a short elimination half-life. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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