The synthesis of dihydroxylated vitamin D metabolites by human renal mitochondria.

Autor: White CP, Richardson RH, Posen S
Jazyk: angličtina
Zdroj: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 1981 Aug; Vol. 53 (2), pp. 450-2.
DOI: 10.1210/jcem-53-2-450
Abstrakt: Mitochondrial preparations from 4 human kidneys produced 1,25-dihydroxycholecalciferol and 24,25 dihydroxycholecalciferol at rates of 0.019 - 0.114 and 0.029 - 0.164 pmol/mg/min respectively at a 25-hydroxycholecalciferol concentration of 1 mumol per litre. Mitochondria from a fifth kidney failed to produce either metabolite.
Databáze: MEDLINE