| Autor: |
Baltzer B, Binderup E, von Daehne W, Godtfredsen WO, Hansen K, Nielsen B, Sørensen H, Vangedal S |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1980 Oct; Vol. 33 (10), pp. 1183-92. |
| DOI: |
10.7164/antibiotics.33.1183 |
| Abstrakt: |
The principle of combining a beta-lactam antibiotic with a beta-lactamase inhibitor in a single molecule functioning as pro-drug for the two active components is illustrated by the linked esters 3 and 4 in which ampicillin and mecillinam, respectively, are combined with the beta-lactamase inhibitor penicillanic acid sulfone. It is shown that in man these esters are excellently absorbed from the gastro-intestinal tract and after absorption hydrolyzed with simultaneous liberation of the active components. As a result high blood and tissue levels of antibiotic and beta-lactamase inhibitor in a balanced ratio are attained. The advantages of "mutual pro-drugs" over simple combinations are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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