[Detection of a distinctive differentiating antigen of activated mouse T- and B-lymphocytes--AKA-1].

Autor: Nesterenko VG, Novikova TK, Fontalin LN, Vekhnik E, Rubakova EI
Jazyk: ruština
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1980 Oct; Vol. 90 (10), pp. 449-51.
Abstrakt: The presence of a differentiative antigen on activated B cells -- antibody forming cells (AFC), analogous to that against mouse T lymphocytes activated by transplantation antigens was demonstrated with the help of specific rabbit antiserum (ATactS) against these T lymphocytes. The antigen was detectable on direct AFC producing antibodies to sheep, rabbit and rat red blood cells as well as on indirect AFC producing antibodies to sheep red blood cells. The antigen was found on AFC of different H-2 and Ala-1 phenotypes. The activity of ATactS was abolished by absorption with activated T cells, EL-4 lymphoma cells rather than by intact lymphocytes, liver cells, serum or immunoglobulin of mice. The differentiative antigen common to activated T and B cells is proposed to be designated Aka-1.
Databáze: MEDLINE