Possible tumor localization of Tc-99m-labeled liposomes: effects of lipid composition, charge, and liposome size.

Autor: Richardson VJ, Jeyasingh K, Jewkes RF, Ryman BE, Tattersall MH
Jazyk: angličtina
Zdroj: Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 1978 Sep; Vol. 19 (9), pp. 1049-54.
Abstrakt: The possible in vivo distribution of liposomes after they have been directly labeled with Tc-99m has been studied in rats bearing the Walker 256 carcinoma. The importance of lipid composition, charge, and size of liposome were studied with respect to possible tumor-localizing properties. Tumor uptake was best with small, fluid-membrane, negatively charged liposomes, as indicated by the distribution of the Tc-99m label. The uptake was visualized on scintigrams.
Databáze: MEDLINE