Relationship between leukemia antigens and stimulation in mixed leukocyte culture.

Autor: Opelz G, Gale RP, McClelland JD
Jazyk: angličtina
Zdroj: Journal of the National Cancer Institute [J Natl Cancer Inst] 1977 Jul; Vol. 59 (1), pp. 95-8.
DOI: 10.1093/jnci/59.1.95
Abstrakt: Leukemia cells from 13 of 27 patients stimulated lymphocytes of their HLA-identical siblings in mixed leukocyte cultures (MLC). Stimulation correlated with high background uptake of tritiated thymidine and high percentages of cells that stained with fluorescein-conjugated polyvalent goat antiserum against human immunoglobulin. Results were similar to those reported with fractionated autologous lymphocyte subpopulations in normal individuals. Investigation of leukemia-specific stimulation in MLC is therefore problematic.
Databáze: MEDLINE