| Autor: |
Lankelma J, Penders PG, McVie JG, Leyva A, Ten Bokkel-Huinink WW, de Planque MM, Pinedo HM |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of cancer & clinical oncology [Eur J Cancer Clin Oncol] 1982 Apr; Vol. 18 (4), pp. 363-7. |
| DOI: |
10.1016/0277-5379(82)90007-4 |
| Abstrakt: |
In 9 patients with advanced malignant disease who received carminomycin (CMM) in an i.v. bolus injection (dose 18 mg/m2), curves of plasma concentrations of CMM and carminomycinol (CMMOH), a metabolite, versus time were constructed. For determination of plasma concentrations, high pressure liquid chromatography was used. For CMM and CMMOH the median areas under the curves (AUC's) were 31 (range 4-57) X 10(-8) mol/Ql/hr (measured over 24 hr) and 100 (range 309-158) X 10(-8) mol/l/hr (measured over 48 hr) respectively. From the data an accumulation of CMMOH in patients receiving treatments separated by brief intervals ban be predicted (half-life time of plasma disappearance for CMMOH was 2 days). Clinical toxicity was lowest in those 3 patients showing the lowest AUC for both CMM and CMMOH. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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