| Autor: |
Shutske GM, Allen RC, Försch MF, Setescak LL, Wilker JC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1983 Sep; Vol. 26 (9), pp. 1307-11. |
| DOI: |
10.1021/jm00363a016 |
| Abstrakt: |
The indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid were synthesized and tested for diuretic activity in saline-loaded mice. Each analogue was found to be less active than the parent benzisoxazole: the diuretic activity followed the order O greater than S greater than N = SO2 in regard to the heteroatom in the 1-position of the ring. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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