| Autor: |
Barnett RA, Aronson SB |
| Jazyk: |
angličtina |
| Zdroj: |
Fundamental and applied toxicology : official journal of the Society of Toxicology [Fundam Appl Toxicol] 1983 May-Jun; Vol. 3 (3), pp. 187-91. |
| DOI: |
10.1016/s0272-0590(83)80080-3 |
| Abstrakt: |
A biomicroscopic method for evaluation of ocular and adnexal toxicity in the white rabbit has been developed. When compared to the Draize method, the biomicroscopic method demonstrates a greater spectrum of clinical signs allowing for better dose-response characteristics. This method was found to be both reproducible and easy to execute. The biomicroscopic method, by defining discrete anatomical entities, allows for a high degree of predictability as to severity of ocular and adnexal toxicity as well as the occurrence of permanent ocular injury. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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