| Abstrakt: |
The data obtained in the study of the immunization properties of experimental and production lots of combined parotitis-measles vaccine prepared at the Pasteur Research Institute for Epidemiology and Microbiology (Leningrad) in 1971-1979 are summarized. The preparation was shown to possess low reactogenicity and, at the same time, high immunogenic activity. The reactogenicity of the preparation depended mainly on the presence of the measles component in the divaccine and its immunogenicity, on the measles virus/parotitis virus ratio in one vaccination dose. The concentration of measles virus between 300 and 10000 infective units and parotitis virus between 5000 and 100000 infective units in one vaccination dose, as well as the age of the vaccinees, did not affect the immunization properties of the divaccine. The use of the combined vaccine in the foci of parotitis infection did not increase the reactogenicity of the preparation, but enhanced its immunogenic properties. |
