| Autor: |
Bloomer WD, McLaughlin WH, Milius RA, Weichselbaum RR, Adelstein SJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of cellular biochemistry [J Cell Biochem] 1983; Vol. 21 (1), pp. 39-45. |
| DOI: |
10.1002/jcb.240210106 |
| Abstrakt: |
Auger effects from 125I decay are singularly damaging if localized in DNA as the thymidine analogue 125I-iododeoxyuridine (125IUdR). Recent experience with steroid sex hormones extends these observations by demonstrating cytotoxicity in sites other than the DNA backbone. We have compared the cytotoxicity in human MCF-7 breast cancer cells of 125IUdR, 125I-iodotamoxifen, a nonsteroidal antiestrogen that is translocated from the cytoplasm to the nucleus of receptor containing cells, and 125I-iodoantipyrine, a biological indicator of the body water space. Cytotoxicity is critically dependent upon subcellular localization. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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