| Autor: |
Hindmarsh KW, Nation RL, Williams GL, John E, French JN |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1983; Vol. 24 (5), pp. 649-53. |
| DOI: |
10.1007/BF00542216 |
| Abstrakt: |
Low birth weight preterm infants with suspected infection were administered gentamicin intramuscularly every 18 h (2.5 mg/kg) or 24 h (3.0 mg/kg). For both dosage regimens plasma gentamicin levels were monitored during a dosage interval on three separate occasions over a 10 day period. Both regimens gave satisfactory plasma concentrations and there was no important statistically significant difference between the two. The body clearance of gentamicin correlated with gestational age (r = 0.76, p less than 0.01). The results indicate either regimen may be useful in the clinical situation but from a practical standpoint administration every 24 h may be easier to comply with then every 18 h. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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