| Autor: |
Mickle DA, Wong PY, Humphrey JG, Griffith K, Mee AV |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical biochemistry [Clin Biochem] 1983 Jun; Vol. 16 (3), pp. 163-6. |
| DOI: |
10.1016/s0009-9120(83)90195-9 |
| Abstrakt: |
Human skeletal muscle acetylcholine receptor (AChR) antibodies were assayed by a double immunoprecipitation technique using 125I-alpha-bungarotoxin as the label. Monkey AChRs were found to be superior to those from diabetic humans for analytical and practical reasons. The analytical sensitivity is 0.05 nmol alpha-bungarotoxin/L serum. The between-run and within-run precision (1 c.v.) of the assay are 13% and 3%, respectively. The normal range is 0-0.2 nmol alpha-bungarotoxin/L. There was no correlation between the antibody concentration and the clinical severity of myasthenia gravis. The clinical sensitivity and specificity of the assay for generalized myasthenia gravis are 79% and 96%, and for ocular myasthenia gravis 29% and 96%, respectively. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
