Changes in the mucosa of colon conduits with particular reference to the risk of malignant change.

Autor: Moorcraft J, DuBoulay CE, Isaacson P, Atwell JD
Jazyk: angličtina
Zdroj: British journal of urology [Br J Urol] 1983 Apr; Vol. 55 (2), pp. 185-8.
DOI: 10.1111/j.1464-410x.1983.tb06552.x
Abstrakt: Intestinal suction biopsies were obtained in 15 infants and children with cutaneous colo-ureterostomies. The patients were subdivided into groups according to the length of time the conduit had been established, i.e. less than 5 years, 5 to 10 years, 10 to 15 years and over 15 years. The histological changes found were chronic inflammation with a dense infiltration of plasma cells and eosinophils. The changes were progressive and correlated with the length of time the conduit had been established. As persistent chronic inflammation is a precursor of malignancy, it seems likely that there is a risk of malignant change in these conduits. Regular follow-up of such patients is recommended and should include flexible fibreoptic endoscopy of the conduit.
Databáze: MEDLINE