Lethality of pentazocine and tripelennamine combinations in mice housed individually and in groups.

Autor: Poling A, Kesselring J, Sewell RG Jr, Cleary J
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1983 Jan; Vol. 18 (1), pp. 103-5.
DOI: 10.1016/0091-3057(83)90258-7
Abstrakt: Lethality of 80 mg/kg pentazocine alone; 40 mg/kg tripelennamine alone; 20 mg/kg tripelennamine in combination with 40, 60, and 80 mg/kg pentazocine; and 40 mg/kg tripelennamine in combination with 10, 20, and 40 mg/kg pentazocine was determined in mice housed individually and in groups. Results indicate that the lethality of pentazocine and tripelennamine combinations in mice is (1) dose-dependent, (2) potentiated relative to either drug alone, and (3) greater in group-housed than in individually-housed animals.
Databáze: MEDLINE