Mesnum as a protector against kidney and bladder toxicity with high-dose ifosfamide treatment.

Autor: Falkson G, Van Dyk JJ, Stapelberg R, Falkson HC
Jazyk: angličtina
Zdroj: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 1982; Vol. 9 (2), pp. 81-4.
DOI: 10.1007/BF00265383
Abstrakt: Thirty-two patients with advanced cancer were treated in a phase I-II trial with ifosfamide plus mesnum. At doses up to 300 mg ifosfamide/kg the administration of mesnum prevented most of the expected kidney and bladder toxicity. With this high dose range hemopoietic dose-limiting. Only one of twelve evaluable patients with breast cancer showed definite therapeutic benefit. Complete remission or partial remission was seen in three patients with non-Hodgkin lymphoma and one patient with Hodgkin's disease.
Databáze: MEDLINE