| Autor: |
Perkins WE, Schroeder RL, Carrano RA, Imondi AR |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of cancer [Br J Cancer] 1982 Oct; Vol. 46 (4), pp. 662-7. |
| DOI: |
10.1038/bjc.1982.251 |
| Abstrakt: |
ICRF-187 was tested for cardioprotective activity in doxorubicin-treated mice and guinea pigs. Pretreatment with i.p. ICRF-187 caused a significant decrease in the indicence of i.v. doxorubicin-induced myocardial histological damage in the mouse. I.p. ICRF-187 did not, however, reduce the effect of i.p. doxorubicin on a functional myocardial effect of this antitumour drug, a reduced histamine responsiveness of right atria in vitro. These data suggest that ICRF-187 may not be specific for all the cardiac effects of doxorubicin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
