| Autor: |
Intoccia AP, Flanagan TL, Walz DT, Gutzait L, Swagzdis JE, Flagiello J Jr, Hwang BY, Dewey RH, Noguchi H |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of rheumatology. Supplement [J Rheumatol Suppl] 1982 Jul-Aug; Vol. 8, pp. 90-8. |
| Abstrakt: |
Gold from orally administered auranofin (AF) was absorbed 17-23% in rats and 15-38% in dogs. Gold was highly bound to blood cells and plasma proteins. Gold terminal half life was 1.2-1.8 days in rat blood and plasma (measured for 7 days post dose) and 19.5 days in the dog (measured for 42 days). Excretion of gold (rat and dog) was via feces (84 and 81%) urine (10 and 16%) and bile (3% of dose). Rat tissue levels of gold were highest in the kidney. Evidence indicated that AF was rapidly degraded to triethylphosphine oxide with the remaining molecular fragments postulated to be a protein-gold complex and acetylthioglucose. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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