| Autor: |
Kadmon D, Heston WD, Lazan DW, Fair WR |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 1982 Nov; Vol. 23 (11), pp. 998-1002. |
| Abstrakt: |
We studied the effect of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, on putrescine uptake by the rat prostate. Using C-14 putrescine, we found a several-fold increase in uptake by both the dorsal and ventral prostates of DFMO-pretreated intact animals, compared with untreated controls. When previously castrated animals were treated with a combination of testosterone and DFMO, the prostatic uptake of exogenously administered C-14 putrescine increased more than tenfold. Under these conditions, DFMO enhanced the uptake by the prostate to a greater extent than by any other tissue studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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